Article 3418

Title of the article

STUDY OF THE IMPACT ON TRAINABILITY OF CERTAIN DERIVATIVES OF 3-OXYPIRIDINE
IN EXPERIMENTAL CHRONIC HEART FAILURE 

Authors

Zamotaeva Mariya Nikolaevna, Candidate of medical sciences, associate professor, sub-department of pharmacology and clinical pharmacology with a course pharmaceutical technology, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: zamy03@mail.ru
Konorev Vladimir Vladimirovich, Postgraduate student, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: konarewv@rambler.ru
Zaytseva Elizaveta Nikolaevna, Student, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: liza-82824@yandex.ru
Semenov Aleksandr Vladimirovich, Candidate of chemical sciences, associate professor, sub-department of organic chemistry, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: salexan@mail.ru
Kuznetsov Yuriy Vasil'evich, Candidate of chemical sciences, senior staff scientist, Laboratory of Antioxidant Chemistry, N. M. Emanuel Institute of Biochemical Physics RAS (4 Kosygina street, Moscow, Russia), E-mail: drk@polymer.chph.ras.ru 

Index UDK

616.12-008.46:615.27 

DOI

10.21685/2072-3032-2018-4-3 

Abstract

The impact of some derivative 3-oxypyridin (3-oxypyridin of succinate, 3-oxypyridin of acetylcysteine, 3-oxypyridin of fumarate, 3-oxypyridin of adipate ester, 3-oxypyridin of hemisuccinate in dose strength 5% from LD50) on the rats learnin ability under the experimental chronic heart insufficiency (oleic sample) in the methodology for conditioned reflex with positive reinforcement (T-maze) was examined. 
The most effective reducing of latency time was identified on the test on preservation of acquired skill in the animals group, using 3-oxypyridin of hemisuccinate in dose strength 22 mg/kg, which suggests positive influence on learning ability and declines in level of anxiety. The reaction time decreased reliably in the group, using 3-oxypyridin of adipate ester in dose strength 40 mg/kg that suggests rats’ memory improving, in other words, consolidation of memorable footprint can occur under the influence of this substance. 

Key words

antioxidants, 3-oxypyridin, T-maze, nootropic activity 

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References

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Дата создания: 17.06.2019 13:26
Дата обновления: 17.06.2019 14:01